Leica SR GSD Microscope System

http://www.leica-microsystems.com/news-media/news/news-details/article/new-widefield-super-resolution-system-for-applications-in-biomedical-research/

New Widefield Super-Resolution System for Applications in Biomedical Research 

With the new Leica SR GSD from Leica Microsystems, scientists can now achieve resolutions far below the limit of diffraction that have never been attained before in widefield fluorescence microscopy. The system is capable of resolving details as small as 20 nanometers.

The Leica SR GSD is based on GSDIM technology (Ground State Depletion followed by Individual Molecule return; exclusively licensed from MPI Goettingen, based on the work of Professor Stefan Hell).

One of the key advantages of the GSDIM method is that it can be used with conventional fluorescence labels routinely applied in fluorescence imaging applications. GSDIM provides the highest resolution possible with a light microscope today, almost equaling that of an electron microscope.

The Leica SR GSD is based on a fully automated TIRF system (Total Internal Reflection Fluorescence). Combining the benefits of super-resolution with TIRF microscopy is one of many options. The system can also be used for a wide range of applications in all areas of live cell microscopy and high-end fluorescence microscopy.